LmCen

• Tác giả: Mohammed Abdo Saghir Abbas, Thouraya Boussoffara, Ifhem Chelbi, Saifedine Cherni, Lais da S Pereira, Khalil Dachraoui, Ranadhir Dey, Sreenivas Gannavaram, Shinjiro Hamano, Hirotomo Kato, Swarnendu Kaviraj, Imen Labidi, Hechmi Louzir, Patrick Lypaczewski, Greg Matlashewski, Nourhane Msallem, Hira L Nakhasi, Abhay R Satoskar, Kamaleshwar P Singh, Sanjay Singh, Malek Trimèche, Sanjay Varikuti, Wen-Wei Zhang, Elyes Zhioua
• Ngôn ngữ: eng
• Thông tin xuất bản: England : NPJ vaccines , 2025
• Bộ sưu tập: NCBI
• ID: 100949

Tóm tắt

Dogs are the main reservoir host of Leishmania infantum, etiological agent of zoonotic visceral leishmaniasis (ZVL). An effective vaccine against Canine Visceral Leishmaniasis (CVL) will help the control and elimination of ZVL. In this study, we evaluated in dogs the safety, immunogenicity, and efficacy of a live attenuated Leishmania major Centrin gene-deleted (LmCen