Performance of homozygosity by descent in two mice lines divergently selected for birth weight environmental variability.

• Tác giả: Isabel Cervantes, Nora Formoso-Rafferty, Juan Pablo Gutiérrez, Candela Ojeda-Marín
• Ngôn ngữ: eng
• Ký hiệu phân loại: 641.5612 Cooking
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 102709

Tóm tắt

Inbreeding can have negative effects, such as increasing the expression of deleterious alleles or reducing fitness. A method based on Hidden Markov Models (HMM) was developed to determine the probability of an individual genome in a homozygous-by-descent state (HBD). As a result of an experiment of divergent selection for birth weight environmental variability two lines were created: high variability line (H-Line) and low variability line (L-Line). The L-Line demonstrated a better performance in traits related with robustness than the H-Line. From a selection period of 20 generations, a total of 655 individuals from the H-Line and 675 individuals from the L-Line were genotyped with a high-density SNP array. We used a predefined multiclass HMM with a total of 9 age related HBD classes and 1 non HBD class. The sum of the probabilities of each HBD class was defined as the total HBD inbreeding (F