Nonsense-mediated mrna decay in human disease : an approach for personalized medicine

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Tác giả: Jieshuang Jia, Fabrice LejeuneFabrice Lejeune

Ngôn ngữ: eng

ISBN-13: 978-0128044681

Ký hiệu phân loại: 616.042 Genetic diseases (Hereditary diseases)

Thông tin xuất bản: Boston, MA : Elsevier, 2016.

Mô tả vật lý: ix, 180 pages : , color illustrations ; , 23 cm

Bộ sưu tập: Khoa học ứng dụng

ID: 104672

Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.
Includes bibliographical references and index.
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