OBJECTIVE: This study aims to investigate the factors contributing to kinesiophobia in patients following percutaneous coronary intervention (PCI). METHODS: Purposive sampling was employed to conduct semi-structured interviews with 14 patients and 4 healthcare professionals who satisfied the inclusion and exclusion criteria, from May 2023 to June 2023. Data were coded, categorized, and thematically analyzed using the Colaizzi seven-step analysis method. RESULTS: The factors contributing to kinesiophobia in patients post-PCI were classified into four primary themes: heightened psychological stress, increased uncertainty regarding exercise, reduced self-efficacy, and inadequate support systems. CONCLUSION: Kinesiophobia in patients post-PCI hinders adherence to cardiac rehabilitation protocols. Early identification and analysis of the factors contributing to kinesiophobia can guide the development and implementation of effective intervention strategies. CLINICAL REGISTRATION NUMBER: Not applicable.