Unravelling the mode of action of the Tres Cantos Antimalarial Set (TCAMS): investigating the mechanism of potent antimalarial compounds potentially targeting the human serotonin receptor.

• Tác giả: Paula J Bartlett, Benedito Matheus Dos Santos, Francisco-Javier Gamo, Celia R S Garcia, Angela Lu, Lenna Rosanie Cordero Mallaupoma, Abhinab Mohanty, Mateus Fila Pecenin, Andrew P Thomas
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Malaria journal , 2025
• Bộ sưu tập: NCBI
• ID: 105706

Tóm tắt

BACKGROUND: Despite the strides made in recent decades, the resistance observed in existing antimalarial drugs, and the intricate life cycle of the Plasmodium parasite underscore the pressing need to develop novel and effective therapeutic interventions. This article provides a comprehensive evaluation of the outcomes stemming from screening a library comprising 48 compounds (TCAMS) against Plasmodium falciparum. METHODS: This study focused on characterizing the IC RESULTS: IC CONCLUSIONS: This study identifies promising antimalarial candidates with low IC