BACKGROUND: Women are typically more prone to knee injuries than men, possibly due to poorer hamstrings-to-quadriceps ratio (HTQ), particularly during fast velocity movements. HYPOTHESIS: Men would have greater HTQ across velocity than women. STUDY DESIGN: Cross-sectional study. LEVEL OF EVIDENCE: 2. METHODS: Ultrasound images quantified quadriceps and hamstrings muscle cross-sectional area (CSA) in 27 study participants (14 women, age, 24 ± 4 years
13 men, age, 25 ± 6 years). Peak torque (PT) was taken from maximal voluntary isometric contractions (MVICs) and isokinetic leg extension and flexion contractions from 60° to 300° s RESULTS: Men had larger CSA and PT than women for leg extension and flexion across velocity ( CONCLUSION: Both groups had similar patterns of response for leg extension PT and HTQ across velocity, with no sex-based differences for HTQ. Factors other than HTQ may account for the potential sex-based difference in knee injury risk. CLINICAL RELEVANCE: Increased knee injury predisposition for women compared with men may be due to neuromuscular control or anatomy rather than HTQ.