Evaluation of tirandamycins with selective activity against Enterococci in the silkworm infection model.

• Tác giả: Taeko Igari, Chihiro Kano, Taichi Ohshiro, Satoshi Ohte, Natsuki Oshima, Taku Sato, Ryuji Uchida, Akiho Yagi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 004.338 Systems analysis and design, computer architecture, performance evaluation of real-time computers
• Thông tin xuất bản: England : The Journal of antibiotics , 2025
• Bộ sưu tập: NCBI
• ID: 105912

Tóm tắt

 In the course of screening for anti-enterococcal antibiotics from microbial resources, a new tirandamycin congener (1), together with four known tirandamycins (2 to 5), were isolated from Streptomyces tirandamycinicus TMPU-20A040. The structures of these tirandamycins were elucidated using NMR and MS analyses
  1 was identified as 12-carboxy tirandamycin A and 2 to 5 as known tirandamycins A (2), B (3), E (4), and J (5). Compounds 1 to 3 exhibited selective anti-Enterococci activity, including vancomycin-resistant strains, with MIC in the range of 1.0 to 64 µg ml