A Bidirectional Mendelian Randomization Study of Tea-Drinking Habits and Risk of Elevated Serum Uric Acid Levels.

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Tác giả: Qian Deng, Nian Liu, Fanyu Meng, Jiangyun Peng, Zining Peng, Xingqiang Wang, Jingjin Wu, Weitian Yan, Weiqing Zhao, Weijian Zhou, Mengyuan Zhu

Ngôn ngữ: eng

Ký hiệu phân loại: 352.1 Jurisdictional levels of administration

Thông tin xuất bản: England : International journal of rheumatic diseases , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 105952

BACKGROUND: Although recent animal experiments have revealed that tea intake improves elevated serum uric acid (SUA) levels, a causal link between the consumption of different types of tea and SUA levels remains undetermined. METHODS: Bidirectional Mendelian randomization (MR) analysis based on genome-wide association studies was used to assess the causal relationship between consumption of different types of tea and the risk of elevated SUA levels in European and Asian populations. RESULTS: Forward MR analysis showed that tea intake was significantly associated with lower SUA levels (p = 0.0013). The estimated effect value ( CONCLUSION: Although this bidirectional MR study provided evidence of a causal relationship between tea intake and SUA levels, however, due to limitations associated with the sample size and strength of instrumental variables, a definite conclusion was not possible.
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