Conspiracy theories and beliefs against LGBTQ+ people are a recurrent theme in the political agenda, depicting them as evil actors in a larger plot, seeking to undermine societal norms, institutions, and traditional values. Lessening LGBTQ+ conspiracy beliefs is crucial to reaching more social equality, and intergroup contact might represent a useful strategy. Study 1 (N = 253) investigated the associations of the quantity of direct contact with LGBTQ+ people, the quality of such contacts, and their interactive role with LGBTQ+ conspiracy beliefs. Taking a step forward, Studies 2 (N = 512) and 3 (N = 529) investigated, correlationally and experimentally, respectively, the relationship between the quality of contact with LGBTQ+ individuals and LGBTQ+ conspiracy beliefs, exploring the mediating associations of intergroup knowledge, empathy, and anxiety. Results consistently suggested that a higher quantity of direct contacts with LGBTQ+ people is negatively associated with LGBTQ+ conspiracy beliefs. Furthermore, positive contact was associated with lower conspiracy beliefs against LGBTQ+ people, with these associations being either partially (Study 2) or fully (Study 3) mediated by intergroup empathy. Overall, these findings highlight the importance of fostering positive intergroup interactions and enhancing empathy as strategies to combat harmful conspiracy beliefs about marginalized groups.