Toxic epidermal necrolysis (TEN) and Steven-Johnson syndrome (SJS) are rare, severe cutaneous reactions often triggered by drug hypersensitivity. These conditions, characterized by varying degrees of skin detachment, are associated with certain medications, particularly antiepileptics and antibiotics. Chloroquine, a widely used antimalarial drug, is generally considered safe, but rarely, it can lead to TEN. We present a case of a three-year-old boy who developed TEN after oral administration of chloroquine for suspected malaria. Despite intensive care, the child experienced complications and eventually succumbed to the consequences of TEN. This case underscores the importance of recognizing the potential life-threatening side effects of chloroquine, especially in regions where it is frequently prescribed, like India. Healthcare professionals should remain vigilant about rare yet severe adverse reactions associated with widely used drugs like chloroquine.