Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms.

• Tác giả: Zhimin Chen, Hong Du, Siming Li, Jiandie D Lin, You Lu, Ziyi Meng, Xiaoxue Qiu, Yuwei Tang, Cong Yan, Linkang Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.07995 Diseases
• Thông tin xuất bản: United States : Cell reports , 2025
• Bộ sưu tập: NCBI
• ID: 111621

Tóm tắt

Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by injury to steatotic hepatocytes that triggers the release of endogenous danger-associated molecular patterns. Recent work demonstrated that exposed lipid droplets (LDs) serve as a pathogenic signal that promotes monocyte infiltration and its maturation into triggering receptor expressed in myeloid cells 2 (TREM2