Myeloperoxidase as a biomarker in periodontal disease: electrochemical detection using printed screen graphene electrodes.

• Tác giả: John J Castillo, Ludy Ortiz, María C Valdivieso
• Ngôn ngữ: eng
• Ký hiệu phân loại: 610.28 Auxiliary techniques and procedures; apparatus, equipment, materials
• Thông tin xuất bản: Japan : Odontology , 2025
• Bộ sưu tập: NCBI
• ID: 112872

Tóm tắt

Periodontal disease is a common oral health issue marked by inflammation and the breakdown of tissues. Early detection of biomarkers associated with periodontal disease (PD) can significantly aid in timely diagnosis and intervention. Myeloperoxidase (MPO) is an enzyme abundantly present in neutrophils and has been associated in the pathogenesis of PD. Here, we present a novel approach for the electrochemical detection of MPO using printed screen graphene electrodes coupled with principal component analysis (PCA) for data analysis. We employed cyclic voltammetry to characterize the electrochemical behavior of MPO using potassium ferrocyanide and hydrogen peroxide. The process was controlled by species diffusion on the electrode surface using a scan rate spanning from 10 to 400 mVs