Unanticipated differences in the rat plasma metabolome of genistein and daidzein.

• Tác giả: Volker Haake, Hennicke Kamp, Gina Montoya, Walburga Seefelder, Bennard van Ravenzwaay
• Ngôn ngữ: eng
• Ký hiệu phân loại: 796.429 Race walking (Heel-and-toe races)
• Thông tin xuất bản: Germany : Archives of toxicology , 2025
• Bộ sưu tập: NCBI
• ID: 112911

Tóm tắt

Genistein (GEN) and daidzein (DAI) are soy isoflavones known to bind to estrogen receptors. Overall health effects of GEN and DAI in humans exhibit a dual nature, presenting both health benefits and concerns related to their interaction with the estrogen receptor. The metabolomes of these isoflavones were determined in 28-day oral studies in male and female Wistar rats to elucidate (1) metabolites changes, (2) compare their metabolomes with other compounds and (3) identify toxicological modes of action (MoA). Dose levels for GEN were 1000 and 300 mg/kg bw by gavage and 1000 and 300 ppm (via diet). DAI gavage dose levels were 1000 and 100 mg/kg bw. Results were evaluated using the MetaMap