BACKGROUND: Individuals with low back pain (LBP) often exhibit weakness and the presence of trigger points in their Gluteus Medius (GMe) muscle. OBJECTIVES: To examine the effectiveness of adding dry needling (DN) for the GMe to standard care of active physical therapy in patients with chronic nonspecific LBP. METHODS: A randomized, prospective, sham-controlled trial was conducted. Participants with chronic nonspecific LBP ( RESULTS: The research group showed greater improvement in pain level compared with control ( CONCLUSIONS: Incorporating DN into physical therapy treatments for chronic nonspecific low back pain, can improve pain level and function. CLINICAL TRIALS REGISTRATION NO: NCT04498572 (clinicaltrial.gov).