Twice or once a day? Filgrastim dosing schedule for peripheral hematopoietic stem cells mobilization.

• Tác giả: Fevzi Altuntaş, Mehmet Bakırtaş, Semih Başcı, Nuran Ahu Baysal, Merih Kızıl Çakar, Mehmet Sinan Dal, Tahir Darçın, Dicle İskender, Ali Kılınç, Derya Şahin, Fatma Nurbüke Şarkışla, Bahar Uncu Ulu, Tuğçe Nur Yiğenoğlu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 305.568 +Alienated and excluded classes
• Thông tin xuất bản: Brazil : Hematology, transfusion and cell therapy , 2025
• Bộ sưu tập: NCBI
• ID: 114383

Tóm tắt

INTRODUCTION: Granulocyte colony-stimulating factor (G-CSF) is the most prevalently used growth factor for peripheral blood hematopoietic stem cell (HSC) mobilization. Most centers split the granulocyte colony-stimulating factor in two daily doses, whereas some centers administer one dose per day. This study aims to investigate the effect of the filgrastim dosing schedule on the quantity of hematopoietic stem cells collected after mobilization in healthy donors. METHODS: A total of 251 healthy donors mobilized in our center were included in the study. Mobilization was either once a day (filgrastim 1 × 10 mg/kg/day) or twice a day (filgrastim 2 × 5 mg/kg/day). RESULTS: White blood cell and peripheral CD34 CONCLUSION: This study revealed that one daily dose of 10 mg/kg filgrastim is as effective as administering the same dose split on two days for an adequate amount of CD34