Filling gaps in population estimates of phthalate exposure globally: A systematic review and meta-analysis of international biomonitoring data.

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Tác giả: Jonathan M Acevedo, Vittorio Albergamo, Anna Carrasco, Linda G Kahn, Robbie S J Manuel, Kristyn A Pierce, Marissa Singer Rosenberg, Leonardo Trasande

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Germany : International journal of hygiene and environmental health , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 114952

Many phthalates have been identified as endocrine-disrupting chemicals because they alter hormone functions throughout the lifespan. Nationally representative biomonitoring data are available from the United States, Canada, and Europe, but data elsewhere are sparse, making extrapolations of related disease and disability burdens difficult. We therefore examined trends in urinary phthalate metabolite concentrations in non-occupationally exposed populations in countries other than the United States, Canada, and Europe, where representative data are already available at the country level. We systematically reviewed studies published between 2000 and 2023 and analyzed changes in urinary phthalate metabolite concentrations across time using mixed-effects meta-regression models with and without a quadratic term for time. We controlled for region, age, and pregnancy status, and identified heterogeneity using Cochran's Q-statistic and I
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