Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness.

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Tác giả: Mahnoor Abid, Eduard Ansaldo, Yasmine Belkaid, Rémy Bosselut, Jerry Kok Yen Chan, Liang Chi, Dan Corral, Jérémie Delaleu, Yiping Fan, Florent Ginhoux, Juraj Kabat, Olena Kamenyeva, Verena M Link, Jia Nie, Cihan Oguz, Andrea C Pichler, Claudia A Rivera, Ana Teijeiro, Katharine Yang, Daniel Yong

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Cell , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 117291

Breastfeeding is an obligatory requirement of mammalian survival. This fundamental process is associated with the adaptation of maternal physiology, including the transformation of the mammary gland into a milk-secreting organ. How maternal immunity contributes to mammary gland remodeling and function remains largely unknown. Here, we show that maternal adaptive immunity plays a critical role in shaping lactogenesis. Specifically, physiological adaptation during pregnancy is associated with thymic involution and a paradoxical enrichment in intraepithelial lymphocyte (IEL) precursors that no longer migrate to the gut but instead preferentially accumulate within the mammary gland. IEL precursors differentiate into T-bet-expressing unconventional CD8αα lymphocytes in an IL-15-dependent manner. Mammary IELs control milk production by favoring the differentiation and maturation of contractile and milk-secreting cells, thereby promoting offspring fitness. Altogether, this work uncovers a contribution of the maternal adaptive immune system in organismal remodeling during pregnancy that is associated with mammary gland development and function.
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