BACKGROUND: Robotics and navigation systems have improved the accuracy and precision of acetabular component placement in total hip arthroplasty (THA). The purpose of this study was to determine if the intraoperative use of a novel mixed-reality (MR) navigation system resulted in accurate acetabular component placement with minimal outliers. METHODS: A series of 79 patients who underwent THA performed by a single surgeon using a novel MR navigation system were retrospectively reviewed. The preoperative planned acetabular component operative inclination (OI) and tilt-adjusted operative anteversion (OA) were collected for each case. At the six-week follow-up, each patient underwent three-dimensional (3D) EOS imaging, which was used to measure the acetabular component placement via validated measuring software. Patients who had bilateral THAs or 3D images that did not have critical bony landmarks visible for measurement were excluded from the study. Absolute error was calculated for both inclination and anteversion. Outliers were defined as any cup position that was outside a range of ± 10 degrees from the preoperatively planned target. RESULTS: A total of 39 patients met the inclusion criteria. The mean planned OI for each patient was 40.8 (range, 40 to 41) degrees, and the mean measured postoperative OI was 40.4 (range, 37 to 46) degrees (P = 0.40), resulting in a mean absolute error of 1.8 (range, zero to five) degrees. The mean planned OA was 30.2 (range, 25 to 35) degrees, and the mean measured postoperative OA was 31.1 (range, 27 to 42) degrees (P = 0.11), resulting in a mean absolute error of 2.0 (range, zero to six) degrees. There were no outliers in either OI or OA. CONCLUSION: The results of this study suggest that the use of MR navigation during THA results in accurate postoperative acetabular component inclination and anteversion relative to the preoperative plan without outliers.