Bacterial infection of the damaged skin area hinders the wound healing process. Photothermal antibacterial therapy has attracted increasing attention. As green, safe, and possessing various bioactive properties, natural plant extracts are a good choice. However, few natural plant extracts exhibit excellent photothermal responsiveness in the near-infrared range, requiring increased concentration and radiation power to achieve satisfactory photothermal therapeutic effects. In this study, the horseradish peroxidase/hydrogen peroxide (HRP/H