BACKGROUND AND AIMS: Nutritional status has a great impact on the prognosis of maintenance hemodialysis patients. Therefore, its management should be a priority, and risk screening frequent and easily implemented, based on the biochemical and clinical routine parameters already available, when the use of more comprehensive tools is not possible. Many tools fit these simple criteria, namely the modified creatinine index, geriatric nutritional risk index, and simple protein energy wasting score. These scores are associated with mortality and morbidity risk in hemodialysis patients. This study aims to confirm that these scores are significantly associated with all-cause mortality and to compare them with malnutrition inflammation score. METHODS: Historical cohort study of hemodialysis patients from 25 outpatient clinics. The nutritional and inflammation status was assessed at baseline with malnutrition-inflammation score, geriatric nutritional risk index, modified creatinine index, and simple protein-energy wasting score. Univariable and multivariable Cox additive regression models were used to analyse data. Partial likelihood ratio tests to compare the performance of non-nested Cox models were used. RESULTS: We analysed 2322 patients, 59% males, 31.7% diabetic, with a median age of 70 years (P CONCLUSION: All the tools were significantly associated with mortality. The geriatric nutritional risk index was the score that performed most similarly to the malnutrition-inflammation score.