Metabolic Responses of Rabbit Corneas to Normoxic and Hypoxic Conditions in the Ex Vivo Eye Irritation Test: an alternative to animal experimentation.

• Tác giả: Gallego Beatriz Isabel, Urbach Marc, Glaudo Markus, Schrage Norbert
• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.9677 Diseases Pathology
• Thông tin xuất bản: England : Experimental eye research , 2025
• Bộ sưu tập: NCBI
• ID: 123074

Tóm tắt

The cornea relies on oxygen for its physiological function and therefore for proper vision. Hypoxia induces significant metabolic and structural changes in in vivo corneal models, which underscore the importance of oxygenation in maintaining corneal function and transparency. This study investigates the impact of hypoxia on corneal metabolism using the live-animal-free Ex Vivo Eye Irritation Test (EVEIT)