Identifying the Copper Coordination Environment Between Interacting Neurodegenerative Proteins: A New Approach Using Pulsed EPR with

• Tác giả: R David Britt, Zikri Hasanbasri, Glenn L Millhauser, Kevin Singewald, Amanda Smart
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.8527 Diseases of nervous system and mental disorders
• Thông tin xuất bản: United States : The Journal of biological chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 123311

Tóm tắt

The trafficking and aggregation of neurodegenerative proteins often involves the interaction between intrinsically disordered domains, stabilized by the inclusion of physiologic metal ions such as copper or zinc. Characterizing the metal ion coordination environment is critical for assessing the stability and organization of these relevant protein-protein interactions but is challenging given the lack of regular molecular order or global structure. The cellular prion protein (PrP