Myrtus communis L, is an edible medicinal plant with fruit berries used to manufacture liquors, aromatise wine, and sweet foods, beside several folk-medicinal uses. The plant is also endemic to Libya, holds promise for its medicinal properties, including anti-inflammatory, antioxidant, wound healing, and appetising effects. This work aims to explore the phytoconstituents present in the seeds and fruit peels of Myrtus communis L by GC-MS and LC-ESI-MS analysis, respectively. The work also demonstrated the in vitro and in silico antioxidant and anti-tyrosinase activities of the plant extracts. GC-MS analysis indicated the presence of 11 fatty acids in the myrtle seeds representing 78.61% of the total seeds' fatty acid contents, where the unsaturated linolenic acid (C