PURPOSE: Assess the feasibility, acceptability, and preliminary efficacy of lay health educators to enhance Hispanic/Latino survivors' knowledge of their cancer history, screening needs, and health-related self-efficacy. METHODS: Hispanic/Latino survivors diagnosed within 5 years were recruited from three clinics and a regional cancer registry. Survivors were randomized to receive a personalized survivorship care plan (SCP
control) or SCP plus telephone session with a bilingual-bicultural lay health educator (intervention). Survivors were reassessed after 3 months. Primary outcomes were feasibility (meeting accrual, n = 60-100) and acceptability of the SCP and education session. Secondary outcomes were changes in survivors' knowledge of their cancer history, screening needs, and health-related self-efficacy. RESULTS: Ninety-fine survivors (median age 55 years, 78% female, 56% low/marginal health literacy) were randomized (n = 48 intervention). Seventy-nine completed the study
most found the SCP useful (82% intervention
68% control)
84% of the intervention group rated the education session useful. Over time, both groups had improved knowledge of their cancer history (accuracy increased from 71.5 ± 16.4% to 73.8 ± 15.0%
p = 0.19) although differences over time and between groups were not statistically significant. At follow-up compared with baseline, participants were more likely to report plans for future screening: cervical (57% versus 31%, p = 0.002)
colorectal (39% versus 26%, p = 0.10). Although the change in self-efficacy did not differ between study groups, self-efficacy significantly improved within the control group over time (0.3
95% CI 0.1, 0.5). CONCLUSIONS: Hispanic/Latino survivors found the SCP and education session acceptable. SCPs alone may improve knowledge and adherence to cancer screening. IMPLICATIONS FOR CANCER SURVIVORS: Provision of a SCP may benefit Hispanic/Latino survivors. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov NCT04081779.