Characterization of lipidic plaque features in association with LDL-C<70 mg/dL and lipoprotein(a) <50 mg/dL.

• Tác giả: Yasuhide Asaumi, Masashi Fujino, Tomohiro Fujisaka, Mariko Harada-Shiba, Satoshi Honda, Masaaki Hoshiga, Takamasa Iwai, Yu Kataoka, Hirofumi Kusumoto, Hideo Matama, Hideaki Morita, Kota Murai, Kazuhiro Nakao, Stephen J Nicholls, Kensaku Nishihira, Teruo Noguchi, Fumiyuki Otsuka, Rishi Puri, Kausik K Ray, Kazushi Sakane, Kenichiro Sawada, Daisuke Shishikura, Kensuke Takagi, Itaru Takamisawa, Yohei Yamauchi, Shuichi Yoneda
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of clinical lipidology , 2025
• Bộ sưu tập: NCBI
• ID: 147821

Tóm tắt

 BACKGROUND: The ongoing residual cardiovascular risks despite lowering low-density lipoprotein cholesterol (LDL-C) levels suggest the need to identify additional drivers associated with atherosclerosis. Circulating lipoprotein(a) [Lp(a)]promotes formation of foam cells via its proatherogenic properties. However, whether a lower Lp(a) level in combination with favorable LDL-C control could induce a more stable form of disease remains unknown. Near-infrared spectroscopy (NIRS) generates maximum lipid-core burden index in 4 mm (MaxLCBI METHODS: We analyzed 439 patients with coronary artery disease (CAD) (554 de-novo target lesions receiving percutaneous coronary intervention) in the REASSURE-NIRS registry (NCT04864171). Clinical characteristics and NIRS-derived MaxLCBI RESULTS: Almost one-third of study subjects (33.4%) exhibited both LDL-C <
  70 mg/dL and Lp(a) <
 50 mg/dL. They were more likely male with a lower frequency of acute coronary syndrome and lipid lowering therapies were more frequently used in those with LDL-C <
  70 mg/dL and Lp(a) <
 50 mg/dL. On NIRS imaging analysis, a smaller MaxLCBI CONCLUSION: Our findings suggest circulating Lp(a) as a potential therapeutic target to stabilize coronary atherosclerosis in CAD patients who achieved LDL-C <
  70 mg/dL.