MAPK and STAT3 Inhibitors Modulate FoxP3 Expression and Regulatory T Cell Function.

• Tác giả: Rafi Ahmad, Selma Cornillot-Clément, Nuria García-Díaz, Ehsan Hajjar, Johannes Landskron, Elise Solli, Kjetil Taskén, Qian Wei
• Ngôn ngữ: eng
• Ký hiệu phân loại: 211.7 Agnosticism and skepticism
• Thông tin xuất bản: Germany : European journal of immunology , 2025
• Bộ sưu tập: NCBI
• ID: 148873

Tóm tắt

Regulatory T cells (Tregs) are a subset of T cells defined by the expression of Forkhead box protein P3 (FoxP3) playing a crucial role in regulating effector T cell activity. Tregs accumulate in the tumor microenvironment facilitating tumor growth. Thus, targeting FoxP3