DNA-Capturing Manganese-Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS-STING Pathway and Maintaining Tumor-Infiltrating CD8

• Tác giả: Minming Chen, Liangzhu Feng, Juxin Gao, Zhuang Liu, Chunjie Wang, Xiaoying Yan, Yifan Yan, Shuai Zhang, Yujie Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 546.541 *Manganese
• Thông tin xuất bản: Germany : Advanced materials (Deerfield Beach, Fla.) , 2025
• Bộ sưu tập: NCBI
• ID: 149013

Tóm tắt

The radiotherapy-induced release of DNA fragments can stimulate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) pathway to prime antitumor immunity, but this pathway is expected to be less potent because of the inefficient cytosolic delivery of negatively charged DNA fragments. In this study, manganese-coordinated chitosan (CS-Mn) microparticles with selective DNA-capturing capacity are concisely prepared via a coordination-directed one-pot synthesis process to potentiate the immunogenicity of radiotherapy. The obtained CS-Mn microparticles that undergo rapid disassembly under physiological conditions can selectively bind with DNA to form positively charged DNA-CS assemblies because of the strong electrostatic interaction between linear chitosan and DNA molecules. They thus enable efficient cytosolic delivery of DNA in the presence of serum to cooperate with Mn