The unique structure of cartilage tissue, characterized by a robust collagen fiber framework and a dynamic proteoglycan hydrogel filling, is crucial for maintaining biomechanical and biochemical homeostasis. Herein, a cartilage-inspired microsphere with sponge framework and hydrogel filling (SponGel MS) is successfully prepared to restore cartilage homeostasis. Specifically, epigallocatechin gallate nanoparticles coated with MnO