Cancer signaling : from molecular biology to targeted therapy

• Tác giả: Oliver Müller, Carol Stocking, C Wagener
• Ngôn ngữ: eng
• ISBN-13: 978-3527336586
• Ký hiệu phân loại: 571.74 Biochemistry of control
• Thông tin xuất bản: Weinheim : Wiley-VCH Verlag GmbH & Co.KGaA, 2017
• Mô tả vật lý: xxix, 324 pages : , many color illustrations ; , 25 cm.
• Bộ sưu tập: Khoa học tự nhiên
• ID: 153048
• Chủ đề: 1. Cancer--Molecular aspects; 2. Cancer--Treatment; 3. Cancer cells; 4. Cellular signal transduction; 5. Protein-tyrosine kinase; 6. Tumors; 7. Cell Transformation, Neoplastic; 8. Molecular Targeted Therapy; 9. Protein Kinase Inhibitors--therapeutic use; 10. Signal Transduction

Includes bibliographical references and index.

Tóm tắt

"Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells... "-- Provided by publisher.