BACKGROUND: Retrospective studies and large databases, such as the OneFlorida Clinical Research Consortium, rely on International Classification of Diseases, Tenth Revision (ICD-10) diagnosis codes to identify patients with specificity. This study aimed to determine if ICD-10 codes for CP are overutilized. MATERIALS AND METHODS: Retrospective analysis was conducted for patients with ICD-10 codes K86.0 (alcohol-induced CP) and K86.1 (other CP) from February 2018 to February 2020. Data were extracted from the integrated electronic data repository. This study was approved by the institutional review board. The diagnosis of CP was defined as either being made by a gastroenterologist, proven by biopsy, or having characteristic findings on cross-sectional imaging with appropriate symptoms. RESULTS: Five hundred four (37%) out of the 1360 patients had no evidence of CP. When broken down by diagnosis code, 41 of 176 charts (23.3%) with K86.0 and 461 of 1184 charts (38.6%) with K86.1 had no evidence of CP. Two hundred ninety-nine of these patients had either a single episode of acute pancreatitis, recurrent acute pancreatitis, or episode of acute necrotizing pancreatitis. Of note, 81 patients had no identifiable abdominal pathology. CONCLUSIONS: Although the OneFlorida database makes multicenter research more accessible, it does not replace labor-intensive chart review given the propensity for overdiagnosis.