G protein-coupled receptors in drug discovery : methods and protocols

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Tác giả: Marta Filizola

Ngôn ngữ: eng

ISBN-10: 1493929135

ISBN-10: 1493929143

ISBN-13: 978-1493929139

Ký hiệu phân loại: W1

Thông tin xuất bản: New York : Humana Press, 2015

Mô tả vật lý: xii, 327 pages : , illustrations (many color) ; , 26 cm.

Bộ sưu tập: Khoa học ứng dụng

ID: 156215

This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical, and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists, and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.-- Source other than the Library of Congre
Includes bibliographical references and index.
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