MHC Hammer Decodes HLA Disruption in Tumors.

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Tác giả: Hannah Carter, Timothy Sears

Ngôn ngữ: eng

Ký hiệu phân loại: 912.01 Philosophy and theory

Thông tin xuất bản: United States : Cancer research , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 159740

Tumors utilize various mechanisms of HLA disruption in order to evade immunosurveillance. Previous computational tools have interrogated specific aspects of this process, yet a holistic picture of HLA LOH, transcriptomic suppression, and alternative splicing has remained challenging. In a recent Nature Genetics study, Puttick and colleagues introduced MHC Hammer, a robust computational toolkit designed to dissect the complexities of HLA disruptions that mediate immune evasion in cancer. By analyzing comprehensive genomic and transcriptomic data across several large cancer cohorts, the study highlights the prevalence of HLA disruptions, particularly alternative splicing events, across various tumor types and identifies HLA LOH as an important immune evasion mechanism during metastasis in lung adenocarcinoma.
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