Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo.

• Tác giả: Guoqing Chen, Xingyu Du, Min Gao, Shu Guo, Yuqi Hang, Meiqin Hu, Rong Huang, Ruiying Jiao, Xinjiang Kang, Qian Lei, Jie Li, Yiman Li, Yinglin Li, Zhaohan Lin, Bing Liu, Zhongjun Qiao, Shujiang Shang, Haifeng Shu, Liyuan Sun, Xiaoxuan Sun, Changhe Wang, Lun Wang, Qinglong Wang, Shirong Wang, Yuan Wang, Qihui Wu, Xi Wu, Huadong Xu, Lili Yin, Muhammad Younus, Quanfeng Zhang, Lianghong Zheng, Li Zhou, Zhuan Zhou, Feipeng Zhu, Panli Zuo
• Ngôn ngữ: eng
• Ký hiệu phân loại: 972.8202 *Central America
• Thông tin xuất bản: Germany : Advanced science (Weinheim, Baden-Wurttemberg, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 160063

Tóm tắt

Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic and phasic action potential (AP) firing patterns in behavior mice. Besides AP numbers, whether and how different AP firing patterns per se modulate DA release remain largely unknown. Here by using in vivo and ex vivo models, it is shown that the AP frequency per se modulates DA release through the D2 receptor (D2R), which contributes up to 50% of total DA release. D2R has a voltage-sensing site at D131 and can be deactivated in a frequency-dependent manner by membrane depolarization. This voltage-dependent D2R inhibition of DA release is mediated via the facilitation of voltage-gated Ca