M3-DPPE Liposomal Nanoparticles Encapsulating CLEC12A Enhance CD206-Mediated Endocytosis and Efficacy in the Collagen-Induced Arthritis Model.

• Tác giả: Junfeng Cai, Shuangfeng Ding, Xiaocong Fu, Naoya Kojima, Zheng Liu, Laiya Lu, Shulin Luo, Min Ma, Yunxia Wang, Feng Yin
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS applied bio materials , 2025
• Bộ sưu tập: NCBI
• ID: 160199

Tóm tắt

OBJECTIVE: This study aimed to investigate the efficacy of M3-DPPE liposomal nanoparticles encapsulated with mRNA encoding cytokines (M3-mRNAs) in targeting macrophages for the treatment of inflammation-induced joint injury. CONCLUSIONS: M3-SiCLEC12A enhanced CD206-mediated endocytosis of M3-mRNAs and M3-drugs in macrophages, promoting the production of corresponding proteins and modulating the immune microenvironment. This treatment approach shows promise in repairing inflammation-induced bone and joint injury by balancing pro-inflammatory and anti-inflammatory cytokines. However, further research is required to address drug tolerance and safety concerns and minimize potential side effects before clinical application in autoimmune diseases caused by inflammation.