Melt electrowriting of amorphous solid dispersions: Influence of drug and plasticizer on rheology and printing performance.

• Tác giả: Larissa Keßler, Robert Luxenhofer
• Ngôn ngữ: eng
• Ký hiệu phân loại: 536.42 Fusion (Melting) and solidification
• Thông tin xuất bản: Netherlands : International journal of pharmaceutics , 2025
• Bộ sưu tập: NCBI
• ID: 160208

Tóm tắt

Drug loaded microfiber scaffolds have potential for sublingual or buccal drug delivery due to their fast dissolution time and tunable porosity. Such microfiber scaffolds can be prepared by melt electrowriting (MEW), wherein a polymer melt is electrostatically drawn out of a syringe onto a computer controlled moving collector. The fabrication of such scaffolds via MEW has previously been shown for a polymer with a glass transition temperature (T