Predictive Ability of the Academic Research Consortium High Bleeding Risk Criteria in Patients Undergoing Percutaneous Coronary Intervention According to Body Mass Index.

• Tác giả: George Dangas, Michael Gao, Mauro Gitto, Annapoorna Kini, Parasuram Melarcode Krishnamoorthy, Prakash Krishnan, Roxana Mehran, Pedro Moreno, Angelo Oliva, Samantha Sartori, Samin K Sharma, Kenneth F Smith, Alessandro Spirito, Joseph Sweeny, Birgit Vogel
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.375 Antitoxins, toxin-antitoxins, convalescent serums
• Thông tin xuất bản: United States : Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions , 2025
• Bộ sưu tập: NCBI
• ID: 160361

Tóm tắt

 BACKGROUND: Whether the high bleeding risk (HBR) criteria of the Academic Research Consortium (ARC) have a consistent predictive ability across different categories of body mass index (BMI) remains unclear. METHODS: Consecutive patients undergoing percutaneous coronary intervention (PCI) between 2012 and 2019 at Mount Sinai Hospital (New York, USA) were stratified into five BMI categories (18.5-24.9 kg/m RESULTS: Among 16,123 patients, normoweight, overweight, class I, class II, and class III obesity were found in 23.7%, 41%, 24.5%, 9.3%, 4.8% of patients, respectively. Fulfillment of the ARC-HBR criteria ranged between 34.4% and 48.5% across these BMI categories. One-year rates of major bleeding was 6% in normoweight patients (reference), 4.1% in overweight (adj.HR 0.73, 95% CI 0.60-0.88), 3.5% in class I (adj.HR 0.62, 95% CI 0.49-0.77), 4.2% in class II (adj.HR 0.72, 95% CI 0.54-0.96), and 4.9% in class III (adj.HR 0.83, 95% CI 0.58-1.18) obesity. Consistently across the 5 BMI categories, the fulfillment of ARC-HBR criteria was related with >
  4% rates of major bleeding at 1-year and with ≥ 2 times risk increase of major bleeding (p CONCLUSIONS: The presence of the ARC-HBR criteria predicted a significantly increased risk of major bleeding consistently in each BMI category.