Oral immunization with attenuated Salmonella Typhimurium as a carrier of DNA vaccine against infectious hematopoietic necrosis virus (IHNV) in rainbow trout (Oncorhynchus mykiss).

• Tác giả: Omid Beyraghdar Kashkooli, Seyed Amir Hossein Jalali, Saeed Sepehre Nia, Sabihe Soleimanin-Zad
• Ngôn ngữ: eng
• Ký hiệu phân loại: 302.2242 Communication
• Thông tin xuất bản: England : Fish & shellfish immunology , 2025
• Bộ sưu tập: NCBI
• ID: 160502

Tóm tắt

Infectious hematopoietic necrosis virus (IHNV) is a serious pathogen in the salmonid aquaculture industry and leads to economic losses in the world. This study aimed to develop a new oral DNA vaccine designed to protect rainbow trout against infection by IHNV. Fish were administered via the oral route by the attenuated Salmonella enterica serovar Typhimurium as a carrier of pcDNA3.1-IHNG (glycoprotein (G)) plasmid for 7 days and finally, fish were challenged by 10