Selective Recognition of Oncogene Promoter C-Myc G-Quadruplex: Design, Synthesis, and In Vitro Evaluation of Naphthalimide and Imidazo[1,2-

• Tác giả: Kamaldeep Paul, Palak Sharma
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.525 Selective dissemination of information (SDI)
• Thông tin xuất bản: United States : ACS applied bio materials , 2025
• Bộ sưu tập: NCBI
• ID: 160625

Tóm tắt

c-Myc is a transcription factor that is overexpressed in most human cancers. Despite its challenging nature, we have developed a series of naphthalimide-imidazopyrazine conjugates to target c-Myc. The library of synthesized derivatives was tested for their anticancer activity against a nine-panel of cancer cell lines. Compound