A Haplotype GWAS in Syndromic Familial Colorectal Cancer.

• Tác giả: Mats Lindblad, Annika Lindblom, Wen Liu, Johanna Samola Winnberg, Tilde Sjödin, Veronika Soller, Litika Vermani
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.823 Oil and natural gas
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 160703

Tóm tắt

A previous genome-wide association study (GWAS) in colorectal cancer (CRC) patients with gastric and/or prostate cancer in their families suggested genetic loci with a shared risk for these three cancers. A second haplotype GWAS was undertaken in the same colorectal cancer patients and different controls with the aim of confirming the result and finding novel loci. The haplotype GWAS analysis involved 685 patients with colorectal cancer cases and 1642 healthy controls from Sweden. A logistic regression model was used with a sliding window haplotype approach. Whole-genome and exome sequencing datawere used to find candidate SNPs to be tested in a nested case-control study. In the analysis of 685 colorectal cancer cases and 1642 controls, all ten candidate loci from the previous study were confirmed. Fifty candidate loci were suggested with a