Development of two recombinase-aided amplification assays combined with lateral flow dipstick (RAA-LFD) and real-time fluorescence (RF-RAA) for the detection of Frog virus 3-like ranaviruses.

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Tác giả: Lang Gui, Shishun Gui, Fei Ke, Lishan Liao, Hong Liu, Jie Sun, Jiang Wu, Dan Xu, Lei Zhang, Ziyi Zhang, Xiaocong Zheng, Peng Zhu

Ngôn ngữ: eng

Ký hiệu phân loại: 338.9 Economic development and growth

Thông tin xuất bản: England : Fish & shellfish immunology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 160718

Frog virus 3-like ranaviruses (FV3-like viruses), particularly FV3 (Frog virus 3), represent typical species within the genus Ranavirus, primarily infecting amphibians and reptiles, thereby posing serious threats to aquaculture and biodiversity conservation. We designed a pair of universal primers and a probe targeting the conserved region of the major capsid protein (MCP) genes of FV3-like viruses. By integrating recombinase-aided amplification (RAA) with lateral flow dipstick (LFD) technology and real-time fluorescence (RF) modification, we established RAA-LFD and RF-RAA assays. The limit of detection (LoD) of RAA-LFD was determined to be 35.4 copies/μL under optimized amplification conditions at 35 °C for 15 min. Similarly, the RF-RAA assay exhibited high specificity with a satisfactory LoD of 3.54 × 10
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