Alternative splicing of

• Tác giả: Thilo Dörk, Robert Geffers, Dhanya Ramachandran, Katja Richter, Bianca Schröder-Heurich, Constantin Sylvius von Kaisenberg, Frauke von Versen-Höynck, Ricarda Welz
• Ngôn ngữ: eng
• Ký hiệu phân loại: 371.04 Alternative schools
• Thông tin xuất bản: United States : Physiological genomics , 2025
• Bộ sưu tập: NCBI
• ID: 16130

Tóm tắt

Preeclampsia is a pregnancy specific hypertensive disorder and is associated with an increased postpartum risk of cardiovascular morbidity for both women and their offspring. Previous studies have indicated that cord blood endothelial colony forming cells (ECFCs) are dysfunctional in preeclampsia. The specific mechanisms are not yet fully understood but dysregulation of alternative splicing has been proposed as one of the pathogenic pathways. In order to identify specific targets of alternative splicing in fetal ECFCs, we performed transcriptome-wide differential splicing analyses between cord blood ECFCs from preeclamptic (n=16) and normal pregnancies (n=13). Selected splicing events were validated using fragment length analysis and Sanger sequencing.