Deciphering Binding Potential of Naphthalimide-Coumarin Conjugate with c-MYC G-Quadruplex for Developing Anticancer Agents: A Spectroscopic and Molecular Modeling Approach.

• Tác giả: Saurabh Gupta, Vijay Luxami, Kamaldeep Paul
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS applied bio materials , 2025
• Bộ sưu tập: NCBI
• ID: 161426

Tóm tắt

It has been well accumulated that G-quadruplex (G4-DNA) has great anticancer relevance, and various heterocyclic moieties have been synthesized and examined as potent G4-DNA binders with promising anticancer activity. Here, we have synthesized a series of naphthalimide-triazole-coumarin conjugates by substituting various amines and further examine their anticancer activity against 60 human cancer cell lines at 10 μM. One and five dose concentration results reveal low values of MG-MID GI