Ultrasound-triggered release of vancomycin from a novel spinal device: Antibiotic release and efficacy in vivo.

• Tác giả: Lauren J Delaney, Rachel Evans, Teeto Ezeonu, Flemming Forsberg, Noreen J Hickok, Rachel Hilliard, Gagan Kaushal, Christopher K Kepler, Ji-Bin Liu, Priscilla Machado, Rajkishen Narayanan, Thomas P Schaer, Viren Soni, Asia Winslow, Neil Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.444 *Sound
• Thông tin xuất bản: Netherlands : International journal of pharmaceutics , 2025
• Bộ sưu tập: NCBI
• ID: 161454

Tóm tắt

Post-surgical spinal infection occurs in up to 20 % of patients, despite aggressive peri-operative antibiotic treatments. To improve prophylaxis, we have designed and evaluated an ultrasound-activated prophylactic antibiotic release system to combat post-surgical bacterial survival. Polylactic acid (PLA) clips (1 cm