Comment: 29 pages, 4 figures, 3 tablesThis paper contributes to the literature on treatment effects estimation with machine learning inspired methods by studying the performance of different estimators based on the Lasso. Building on recent work in the field of high-dimensional statistics, we use the semiparametric efficient score estimation structure to compare different estimators. Alternative weighting schemes are considered and their suitability for the incorporation of machine learning estimators is assessed using theoretical arguments and various Monte Carlo experiments. Additionally we propose an own estimator based on doubly robust Kernel matching that is argued to be more robust to nuisance parameter misspecification. In the simulation study we verify theory based intuition and find good finite sample properties of alternative weighting scheme estimators like the one we propose.