INTRODUCTION: Radionuclide therapy including METHODS: A systematic review was conducted by searching relevant databases (Medline Ovid, PubMed, Embase Ovid, CINAHL Complete, Cochrane Library, CENTRAL, Australian New Zealand Clinical Trials Registry, ClinicalTrials.gov, WHO International Trials Registry, Google Scholar) for literature regarding voxel-based dosimetry in radioembolization. RESULTS: A total of 41 papers were included for this systematic review. Review of these studies revealed that voxel-based dosimetry can benefit numerous aspects of radioembolization in radionuclide therapy including predicting tumour response, toxicity and patient survival. Numerous studies also indicated that voxel-based dosimetry in radioembolization is a more accurate approach in establishing a dose-effect relationship in targeted radionuclide therapy when compared to other methods. Despite these promising findings, these studies did not investigate or comment on the accuracy of voxel-based dosimetry. CONCLUSION: The evidence from this review highlights that voxel-based dosimetry can improve treatment efficacy in radioembolization planning. However, further studies are required to validate the accuracy and feasibility of voxel-based dosimetry in clinical practice.