Dithiocarbamate-Based Sequence-Defined Oligomers as Promising Membrane-Disrupting Antibacterial Agents: Design, Activity, and Mechanism.

• Tác giả: Debashis Barik, Shabin N Chathangad, Sovan Lal Das, Anna Jose, Karthika Kannan, Mintu Porel, Sushabhan Sadhukhan, Palliyil Sivadas
• Ngôn ngữ: eng
• Ký hiệu phân loại: 738.143 Firing
• Thông tin xuất bản: United States : ACS applied bio materials , 2025
• Bộ sưu tập: NCBI
• ID: 163512

Tóm tắt

The emerging prevalence of antimicrobial resistance demands cutting-edge therapeutic agents to treat bacterial infections. We present a synthetic strategy to construct sequence-defined oligomers (SDOs) by using dithiocarbamate (DTC). The antibacterial activity of the synthesized library of SDOs was studied using a Gram-positive