Comment: 30 pages, 9 figuresGiven the extreme dependence of agriculture on weather conditions, this paper analyses the effect of climatic variations on this economic sector, by considering both a huge dataset and a flexible spatio-temporal model specification. In particular, we study the response of N-fertilizer application to abnormal weather conditions, while accounting for other relevant control variables. The dataset consists of gridded data spanning over 21 years (1993-2013), while the methodological strategy makes use of a spatial dynamic panel data (SDPD) model that accounts for both space and time fixed effects, besides dealing with both space and time dependences. Time-invariant short and long term effects, as well as time-varying marginal effects are also properly defined, revealing interesting results on the impact of both GDP and weather conditions on fertilizer utilizations. The analysis considers four macro-regions -- Europe, South America, South-East Asia and Africa -- to allow for comparisons among different socio-economic societies. In addition to finding both spatial (in the form of knowledge spillover effects) and temporal dependences as well as a good support for the existence of an environmental Kuznets curve for fertilizer application, the paper shows peculiar responses of N-fertilization to deviations from normal weather conditions of moisture for each selected region, calling for ad hoc policy interventions.