Sulfur mustard (SM) is an extremely toxic chemical warfare agent. Although SM-induced toxicity has long been studied, due to its complexity, the characterization of the precise molecular pathway it targets has been remaining an ongoing area of research. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells (hucMSC-EVs) are natural substances that participate in intercellular communication by delivering microRNA to target cells. Importantly, the microRNA content in EVs can be modified. MiR-146a-5p delivered by EVs were utilized and hucMSCs were further modified with miR-146a-5p mimics or inhibitors to collect EVs that over-(miR-146a-5p