We propose a statistical framework to quantify location and co-location associations of economic activities using information-theoretic measures. We relate the resulting measures to existing measures of revealed comparative advantage, localization and specialization and show that they can all be seen as part of the same framework. Using a Bayesian approach, we provide measures of uncertainty of the estimated quantities. Furthermore, the information-theoretic approach can be readily extended to move beyond pairwise co-locations and instead capture multivariate associations. To illustrate the framework, we apply our measures to the co-location of occupations in US cities, showing the associations between different groups of occupations.