Comment: 24 pages, 7 figures, 1 table. In Oxford Research Encyclopedia of Environmental Science. Oxford University PressEconomic assessment in environmental science concerns the measurement or valuation of environmental impacts, adaptation, and vulnerability. Integrated assessment modeling is a unifying framework of environmental economics, which attempts to combine key elements of physical, ecological, and socioeconomic systems. Uncertainty characterization in integrated assessment varies by component models: uncertainties associated with mechanistic physical models are often assessed with an ensemble of simulations or Monte Carlo sampling, while uncertainties associated with impact models are evaluated by conjecture or econometric analysis. Manifold sampling is a machine learning technique that constructs a joint probability model of all relevant variables which may be concentrated on a low-dimensional geometric structure. Compared with traditional density estimation methods, manifold sampling is more efficient especially when the data is generated by a few latent variables. The manifold-constrained joint probability model helps answer policy-making questions from prediction, to response, and prevention. Manifold sampling is applied to assess risk of offshore drilling in the Gulf of Mexico.